Molecular Docking Of Withanolides From Withania Somnifera Against Vimentin Protein

Abstract

Ashwagandha, scientifically known as Withania somnifera Dunal, is an important medicinal plant in the Ayurvedic system of medicine. The roots are highly valued and are used either alone or in combination with other medicinal plants to treat a variety of ailments. It is also used as a general tonic, to increase and to improve the overall health and longevity. Regular consumption of ashwagandha is believed to prevent diseases in individuals of varied ages and health conditions. Preclinical studies have shown that Ashwagandha Rasayana possesses radioprotective effects and reduces the radiation-induced emaciation, decrease in the organ weight and to decrease radiation-induced increase in serum transaminase levels. The body weight along with the levels of hemoglobin, red blood cells, white blood cells, and platelets was restored. Aswaghandha is consider to be the nature gift to mankind, it has a potencial significance for targeting the cancerous compounds present in body. Therefore, it is interested to dock Aswaghandha against vimentin protein found in humans (Homo sapiens) with the help of molecular docking tool autodock vina which not only helps in discovering of drugs but also shows the virtual screening, high performance and enhanced accuracy of the drugs.