Deficiency Of Serum 25-Hydroxy Vitamin D Level In Humans Belong To High Rainfall And High Altitude Area Of Indian Region

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Prabhanshu Kumar
Vishal Haribhai Patel
Sanjeev Kumar
Arjun Khanna
Nahid Siddiqui
Kusuma Kumari
Nidhee Chaudhary
Pawan Kumar Maurya

Abstract

Vitamin D is the only secosteroid, a prohormone produced endogenously in dermis under the influence of ultraviolet-B irradiation (UVB 280-315 nm) on bare skin from 7- dehydrocholesterol which is converted into pre-vitamin D3 and then to vitamin D3 (cholecalciferol). The present study has been carried out to investigate the relationship between 25-hydroxyvitamin D [25(OH)D] and decreased exposure to sunlight at a place where rainfall is high and thus outdoor activities are limited. The study is carried out in northern Himalayan part of India, in population based at near Dharamsala town (32°16'N, 76°23'E) in state of Himachal Pradesh, India. The region around town is one of the wettest places in country and thus longer periods of overcast sky with clouds and relatively long winters. Although firm consensus on the optimal levels of serum 25(OH)D levels regarding deficiency, insufficiency, sufficiency and toxicity has not been reached but widely accepted levels in ng /dl viz. deficiency less than 20, insufficiency 20-29, sufficiency 30-100 and toxic less than 150 for interpretation and analysis exist. The results established that population residing at places receiving low sunlight have low level of vitamin D and need supplementary vitamin D and modification in life style.

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How to Cite
Kumar, P., Patel, V., Kumar, S., Khanna, A., Siddiqui, N., Kumari, K., Chaudhary, N., & Maurya, P. (2017). Deficiency Of Serum 25-Hydroxy Vitamin D Level In Humans Belong To High Rainfall And High Altitude Area Of Indian Region. Indian Research Journal of Genetics and Biotechnology, 9(04), 551 -. https://doi.org/.
Section
Review Article